ea0063p1020 | Interdisciplinary Endocrinology 2 | ECE2019
Patalano Roberta
, Pivonello Claudia
, Monto Tatiana
, Simeoli Chiara
, Negri Mariarosaria
, Di Gennaro Gilda
, Papa Fortuna
, de Angelis Cristina
, Cristina De Martino Maria
, Pivonello Rosario
Cushings Syndrome (CS) is associated with a severe myopathy mainly affecting type 2 muscle fibres, with a higher prevalence in male subjects. The excess of glucocorticoids (GC) levels represents the most common cause of myopathy due to an alteration of protein metabolism. The non-coding post-transcriptional gene regulators muscle-specific microRNAs (miRNA) control muscle development and differentiation but when dysregulated lead to skeletal muscle (SM) disorder. The aim ...